Name: Anton Vladimirovich Lopukhov

Title (academic degree): Ph.D.

Speciality: Chemistry

e-mail: lopukhov@enzyme.chem.msu.ru

1、Personal profile

Experienced researcher focused on the field of targeted drug delivery of nanomedicines. Is skilled in variety of practical fields including bionanotechnology, nanomaterials synthesis (organic synthesis, polymer synthesis, nanoparticle formulation, bioconjugation techniques), structural and biochemical characterization (GPC, NMR, DLS, NTA, IR- and UV-spectroscopy, SPR spectroscopy, ICP-MS, MALDI/TOF-MS, enzyme kinetic assay), computational chemistry (molecular dynamics, docking), aseptic cell culture techniques, molecular biology techniques. Dedicated to deliver high-quality research on the cross-edge of chemistry, molecular biology, bionanotechnology areas.

Holds significant teaching experience in related areas, including courses “Biochemistry”, “Mechanisms of Enzyme Catalysis”, “Physical chemistry of enzymes”, “Chemical foundations of biological processes”, “Molecular Biotechnology” and practical courses "Fundamental and Applied Enzymology", "Nanobiomaterials and Nanobiotechnology".

2、Educational experience

2009 – 2014 Faculty of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russia, Degree: Specialist (M.S. equivalent) in Chemistry (Chemical kinetics and catalysis)

2014 – 2018 Faculty of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russia, Degree: Candidate of Chemical Sciences (2022) (Ph.D. equivalent) in Chemistry (Biotechnology)

3、Work experience

2014 – 2022 Junior research scientist, Faculty of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russia

2016 – 2017 Visiting Scholar, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States (Supervisor: Dr.Sci., Ph.D., Prof. A.V. Kabanov)

2022 – 2025 Senior Lecturer, Faculty of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russia

2025 – present. Associate Professor, Faculty of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russia

4、Selected papers (in last 5 years)

1. Klyachko, N.L., Haney, M.J., Lopukhov, A.V., & Le-Deygen, I.M. (2024). Cationized extracellular vesicles for gene delivery. Scientific Reports, 14(1), 25818 (IF 3.8)

2. Tarabarova A.G., Lopukhov A.V., Fedorov A.N., Yurkova M.S. (2024), Novel His-tag Variants for Insertion Inside Polypeptide Chain, ACS Omega, 9(1), 858-865 (IF 4.1)

3. Rakhimbekova, A., Lopukhov, A., Klyachko, N., Kabanov, A., Madzhidov, T. I., & Tropsha, A. (2023). Efficient design of peptide-binding polymers using active learning approaches. Journal of Controlled Release, 353, 903-914, DOI: 10.1016/j.jconrel.2022.11.023 (IF 9.776)

4. Petrov, R. A., Petrov, S. A., Grishin, D. A., Kolmakov, I. G., Abramchuk, D. S., Tkachenko, V. T., Lopukhov, A.V., Beloglazkina, E. K. (2023). Synthesis and Affinity of Novel Triantennary Ligands for the Asialoglycoprotein Receptor. Russian Journal of Organic Chemistry, 59(2), 224-236 (IF 0.8)

5. Maklakova, S. Y., Mazhuga, M. P., Lopukhov, A. V., Gibadullina, K. R., Klyachko, N. L., Majouga, A. G., Beloglazkina, E. K. (2023). Synthesis and Inhibitory Activity of Atorvastatin Conjugate with a Branched Asialoglycoprotein Receptor Ligand Containing Three N-Acetyl-d-galactosamine Residues. Russian Journal of Organic Chemistry, 59(2), 270-279 (IF 0.8)

6. Maklakova, S. Y., Lopukhov, A. V., Khudyakov, A. D., Kovalev, S. V., Mazhuga, M. P., Chepikova, O. E., Beloglazkina, E. K. (2023). Design and synthesis of atorvastatin derivatives with enhanced water solubility, hepatoselectivity and stability. RSC Medicinal Chemistry, 14(1), 56-64. (IF 4.1)

7. Yamansarov E.Yu, Lopatukhina E.V., Evteev S.A., Skvortsov D.A., Lopukhov A.V., Kovalev S.V., Vaneev A.N., Shkil’ D.O., Akasov R.A., Lobov A.N., Naumenko V.A., Pavlova E.N., Ryabaya O.O., Burenina O.Yu, Ivanenkov Y.A., Klyachko N.L., Erofeev A.S., Gorelkin P.V., Beloglazkina E.K., Majouga A.G. (2021). Discovery of Bivalent GalNAc-Conjugated Betulin as a Potent ASGPR-Directed Agent against Hepatocellular Carcinoma. Bioconjugate Chemistry, 32(4), 763-781 (IF 4.031)

8. Lopukhov A.V., Zigang Y., Haney M.J., Bronich T.K., Sokolsky-Papkov M., Batrakova E.V., Klyachko N.L., Kabanov A.V. (2021). Mannosylated Cationic Copolymers for Gene Delivery to Macrophages. Macromolecular bioscience, 21(4), 1-14 (IF 4.979)

9. Petrov R.A., Mefedova S.R., Yamansarov E.Yu, Maklakova S.Yu, Grishin D.A., Lopatukhina E.V., Burenina O.Y., Lopukhov A.V., Kovalev S.V., Timchenko Y.V., Ondar E.E., Ivanenkov Y.A., Evteev S.A., Vaneev A.N., Timoshenko R.V., Klyachko N.L., Erofeev A.S., Gorelkin P.V., Beloglazkina E.K., Majouga A.G. (2020). New Small-Molecule Glycoconjugates of Docetaxel and GalNAc for Targeted Delivery to Hepatocellular Carcinoma. Molecular Pharmaceutics, 18(1), 461-468 (IF 4.321)

10. Reshitko, G.S., Yamansarov E.Yu., Evteev S.A., Lopatukhina, E.V., Saltykova, I.V., Kovalev S.V., Lopukhov A.V., Lobov, A.N., Burenina, O.Y., Klyachko, N.L., Garanina, A.S., Dontsova, O.A., Ivanenkov, Y.A., Gorelkin P.V., Beloglazkina, E. K., and Majouga, A. G. (2020). Synthesis and evaluation of new trivalent ligands for hepatocyte targeting via the asialoglycoprotein receptor. Bioconjugate Chemistry, 31(5), 1313-1319 (IF 4.031)

11. Olshanova, A.S., Yamansarov, E.Y., Seleznev, E.I., Kovalev, S.V., Lopukhov, A.V., Skvortsov, D.A., Evteev, S.A., Klyachko, N.L., Beloglazkina, E.K., Ivanenkov, Y.A., and Majouga, A.G. (2020). Synthesis of a new betulinic acid glycoconjugate with N-acetyl-d-galactosamine for the targeted delivery to hepatocellular carcinoma cells. Russian Chemical Bulletin, 69(1), 158-163 (IF 1.222)